In the spirit of cooperation, we encourage the sharing of knowledge, best practice, research and news.

The UPR Molecular Sciences and Research Center is a 152,000 sq. ft. advanced research facility with  laboratories conducting basic and translational biomedical research in the areas of protein structure and dynamics, molecular biology, genomics, proteomics, bio-imaging, pharmacogenetics, and neurosciences.  Inaugurated in 2011 it now houses over 300 researchers, students and technicians. The primary goal of the MSRC is to produce a significant increase in competitively funded forefront scientific research by scientists at UPR. The MSRC is the UPR System’s first multidisciplinary environment, designed to meet the needs of cutting-edge research in Puerto Rico for the foreseeable future. This new research space design paradigm features standardization, flexibility and adaptability, systems integration, and ease of sharing equipment and human resources.


  • Strengthen research infrastructure and research disciplines of tradition in PR as foundations of a knowledge-based economy.
  • Bridge basic research disciplines with clinical research to foster Translational Research and Technological Innovation.
  • Enrich our society with an “open research culture” by exposing research activities, new technology, training opportunities and discoveries.
  • Develop world-wide recognized Research Centers in areas of Cutting-Edge Scientific Impact through high level of intra- and inter-institutional collaborations.
  • Develop partnerships and collaborations with industry.
  • Enhance UPRs intellectual property (IP) portfolio and the  commercialization of research inventions in PR.

Latest News

Verano Virtual 2021

Casa abierta

Casa Abierta | Centro de Investigación en Ciencias Moleculares

CDI Laboratories abre sede tras inversión de $17 millones

Empresa de biotecnología creará 136 empleos en cinco años, CDI es compañero del MSRC en el proyecto de la vacuna del VIH.

UPR Bayamón y el Centro Molecular firman histórico acuerdo

Con el propósito de que la facultad y los estudiantes de la UPR-Bayamón puedan utilizar las facilidades y el equipo disponible en el Centro Molecular en sus investigaciones y experimentos científicos


Despite Devastation, They—and Their Science—Go On

In the aftermath of Hurricane Maria, five students from the University of Puerto Rico continued their research at a national laboratory 1,600 miles to the north—thanks to Brookhaven Lab’s Office of Educational Programs, mentors, and a scholarship fund created in honor of a late Brookhaven biologist.


Aprueban proyecto para desarrollar el cáñamo industrial

El cáñamo es una planta de la que se obtiene tela para hacer ropa, aceite, material de construcción y semillas para consumo humano, entre otros


Promueven investigaciones de científicos en la Isla

El Dr. Torsten Stelzer, catedrático de la Escuela de Farmacia del RCM, presentó sus investigaciones para la creación de métodos de purificación y formulación continua para fármacos.


Expectativa de patentes en nano tecnologia

Crean centro de nanotecnología ambiental en UPR con propuesta de $5 millones. El Dr. Carlos Cabrera sera el director del mismo.

Eduardo Nicolau

Iniciativa académica en UPR Río Piedras une la ciencia y el empresarismo

Como parte de los esfuerzos para que los universitarios desarrollen destrezas de emprendimiento, el profesor, Eduardo Nicolau, imparte un curso en el cual se entrelazan la ciencia y el empresarismo.


Creating Solutions With Nanoparticle Chemistry

Dr. Nicolau currently supervises 8 graduate students, and has supervised 30 undergraduates since his appointment as an Assistant professor by the Department of Chemistry at the University of Puerto Rico Río Piedras.

TED2012: Full Spectrum. February 27 - March 2, 2012. Long Beach, CA. Photo: Ryan Lash/TED

The Vaccine Against HIV

Hace 33 años se descubrió el virus de inmunodeficiencia humana. Hay sobre 35 millones de personas infectadas actualmente en el mundo. Esta charla explora los retos que implican el desarrollo de una vacuna para evitar la infección y discute las nuevas esperanzas en este campo científico, en el que Puerto Rico juega un papel importante.


Centros de investigación de la UPR cautivan a la NASA

La NASA visita el Instituto de Aeronáutica y Aeroespacial de Puerto Rico


Avanza la investigación sobre vacuna contra el VIH en P. R.


Avanza en Puerto Rico la investigación con marihuana medicinal


Cautivadora experiencia en investigación química para estudiantes de escuela superior


Doctora boricua lucha por la prevención de casos de labio leporino infantil


Avanza la investigación sobre vacuna contra el VIH en P. R.


P.R. pudiera convertirse en autoridad mundial en la producción de vacunas contra el VIH

Core Facilities

Integrating confocal microscopy and electrophysiology

Neuroimaging and Electrophysiology Facility (NIEF) is a core research facility for fluorescent microscopy and electrophysiology applications. NIEF is also world renowned as a Nikon Center of Excellence. We offer a range of services to meet your research needs, from the acquisition and analysis of fluorescence-based images and electrophysiology recordings to hands-on training in microscopy and electrophysiology. At the NIEF, you will have the opportunity to capture high-quality confocal images of subcellular structures and molecular events with great sensitivity and high speed as well as the detection of action potentials and ion channel currents from primary and recombinant cells to cellular tissues and animal models.

Crystallization Design Institute, formed in 2015

The Institute was founded by Dr. Vilmalí López-Mejías and Dr. Torsten Stelzer with the mission of providing technical services and unparalleled expertise ranging from materials design to crystallization process development. It is focused on providing molecular and engineering solutions to pressing challenges in materials design and crystallization process development.

SGF has been providing services for projects since 2006

The Facility collaborates closely with the High Performance Computing Facility at the UPR, creating opportunities for undergraduate and graduate students to experience and learn latest technological advances and the bioinformatics tools needed to analyze these large datasets as well as providing ample project consulting and training.

A Comprehensive Solution to Process Development of Biopharmaceuticals

The University of Puerto Rico (UPR) and CDI Laboratories have partnered to provide comprehensive solutions for process development. The CDI facility, based in Mayaguez, performs protein expression trials and develops purification schemes. The UPR facility, based in the MSRC, develops tailored analytical tools for a wide array of biological products in a good manufacturing practice environment. Our goal is to streamline the process development pipeline of a promising biotherapeutic from lead to clinic.

The facility has the capability of running a broad range of applications including GC / MS, HPLC / MS, analysis of volatile organic compounds by headspace, direct insertion probe, direct injection, as well as analysis of polymers or protein materials. This facility includes:

  • Bruker Scion TQ GC-MS- MS,
  • Waters Xevo G2-S Q-TOF
  • HPLC-UV Alliance 2695
  • Q-Tof Micro Ms/MS

The NMR Lab. includes 4 NMR spectrometers:

  • Bruker Avance DPX-300 with multinuclear and variable temperature capability used for routine samples.
  • Bruker Avance AV-500 with multinuclear capabilities equipped with a broadband auto tunable probe with gradients.
  • Bruker Ascend Aeon 700 with multinuclear, variable temperature and cross polarization magnetic angle spinning.
  • Bruker Ascend Aeon 500 with Ultra Shield Aeon Magnet, which eliminates liquid nitrogen from magnet and minimizes helium refills to small volume top-off every 1-2 years. It is equipped with a Prodigy cryoprobe PH5010, an ultra-high sensitivity Multinuclear (5mm sample diameter), including high sensitivity 2H lock channel. It is ideally suited for research applications in chemistry demanding highest sensitivity for X nuclei with 1H decoupling as well as excellent 1H or 19F observe sensitivity. The broadband channel covers a wide range of nuclei from 31P to 15N. Standard temperature range: -40° to 80°C.

The surface microscopy equipment includes:

  • JEOL 6480LV scanning electron microscopes (SEM) with low vacuum and X-ray fluorescence (EDAX) capabilities
  • Digital Instrument Nanoscope IIIA Atomic Force (AFM)
  • Scanning Tunneling (STM) Microscopes
  • PHI Physical Electronics 5600 ESCA System
  • Nicolet IS 50 FT-IR Spectrometer and Continuum IR Microscope
  • Thermo Scientific DXR Raman Imaging Microscope
  • Bruker Tensor 27 and Helios attenuated total Reflectance Spectrometer
  • Bruker Lumus Microscope

This facility is equipped with a Rigaku SmartLab diffraction system. Complementary analysis performed at the facility are:

  • Thermal Gravimetric Analysis (TGA)
  • Differential Scanning Calorimetry (DSC)
Skip to toolbar