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Real-Time Detection of Telomerase Activity in Cancer Cells using a Label-Free Electrochemical Impedimetric Biosensing Microchip.

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Identification of novel protein domains required for the expression of an active dehydratase fragment from a polyunsaturated fatty acid synthase.

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Structure, activity, and substrate selectivity of the Orf6 thioesterase from Photobacterium profundum.

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Structures, semisyntheses, and absolute configurations of the antiplasmodial α-substituted β-lactam monamphilectines B and C from the sponge Svenzea flava.

Avilés E, Prudhomme J, Le Roch KG, Rodríguez AD. Structures, semisyntheses, and absolute configurations of the antiplasmodial α-substituted β-lactam monamphilectines B and C from the sponge Svenzea flava. Tetrahedron. 2015 Jan 21;71(3):487-494.

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Dactyloditerpenol acetate, a new prenylbisabolane-type diterpene from Aplysia dactylomela with significant in vitro anti-neuroinflammatory activity.

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Two rare-class tricyclic diterpenes with antitubercular activity from the Caribbean sponge Svenzea flava. Application of vibrational circular dichroism spectroscopy for determining absolute configuration.

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Simultaneous structure-activity studies and arming of natural products by C-H amination reveal cellular targets of eupalmerin acetate.

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Draft genome sequences of five novel polyketide synthetase-containing mouse Escherichia coli strains.

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Esmail MY, Qi P, Connor AB, Fox JG, García A. Generating chimeric mice by using embryos from nonsuperovulated BALB/c mice compared with superovulated BALB/c and Albino C57BL/6 mice. Journal of the American Association for Laboratory Animal Science 55(4): 400-405, 2016.

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Laser- assisted in vitro fertilization facilitates fertilization of vitrified-warmed C57BL/6 mouse oocytes with fresh and frozen-thawed spermatozoa, producing live pups.

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Differential virulence of clinical and bovine-biased enterohemorrhagic Escherichia coli O157:H7 genotypes in piglet and Dutch belted rabbit models.

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Catalytic effect of ultrananocrystalline Fe3O4 on algal bio-crude production via HTL process.

Rojas-Pérez A, Diaz-Diestra D, Frias-Flores CB, Beltran-Huarac J, Das KC, Weiner BR, Morell G, Díaz-Vázquez LM. Catalytic effect of ultrananocrystalline Fe3O4 on algal bio-crude production via HTL process.

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Surface analysis and electrochemistry of a robustcarbon-nanofiber-based electrode platform H2O2 sensor

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Cerium oxide as a promoter for the electro-oxidation reaction of ethanol: in situ XAFS characterization of the Pt nanoparticles supported on CeO(2) nanoparticles and nanorods.

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Graphene oxide as a protein matrix: influence on protein biophysical properties.

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Implementation of Various Modalities of the Optical-Optical Double Resonance Techniques To Simplify the Interpretation of the Spectra of Highly Excited States of Nitric Oxide.

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Assembly of a Cost-Effective Anode Using Palladium Nanoparticles for Alkaline Fuel Cell Applications.

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Real-Time Detection of Telomerase Activity in Cancer Cells using a Label-Free Electrochemical Impedimetric Biosensing Microchip

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Screening for liver cancer during transplant waiting list: a multicenter study from South America.

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Synthesis and electrocatalytic properties of H2SO4 -induced (100) Pt nanoparticles prepared in water-in-oil microemulsion.

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Influence of nanostructured ceria support on platinum nanoparticles for alkaline methanol Electrooxidation

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Evaluation of an externally interfaced forward osmosis and bio-electrochemical system for energy recovery and wastewater reclamation

Nicolau, E.; Fonseca, J.; Rodríguez-Martínez, J.; Richardson, Tra-My; Flynn, M.; Griebenow, K.; Cabrera, C.R.

 

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Real-Time Detection of Telomerase Activity in Cancer Cells using a Label-Free Electrochemical Impedimetric Biosensing Microchip

Cunci L, Vargas MM, Cunci R, Gomez-Moreno R, Perez I, Baerga-Ortiz A, Gonzalez CI, Cabrera CR. Real-Time Detection of Telomerase Activity in Cancer Cells using a Label-Free Electrochemical Impedimetric Biosensing Microchip.

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The role of HuR in the post-transcriptional regulation of interleukin-3 in T cells.

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Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1

Lasalde C, Rivera AV, León AJ, González-Feliciano JA, Estrella LA, Rodríguez-Cruz EN, Correa ME, Cajigas IJ, Bracho DP, Vega IE, Wilkinson MF, González CI.

Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1. Nucleic Acids Res.

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Intracellular Delivery of siRNA by Polycationic Superparamagnetic Nanoparticles

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Pharmacogenetics of healthy volunteers in Puerto Rico.

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Molecular Cloning and Characterization of a (Lys)(6)-Tagged Sulfide-Reactive Hemoglobin I from Lucina pectinata.

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Setleis syndrome: clinical, molecular and structural studies of the first TWIST2 missense mutation.

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Pharmacogenetic association study of warfarin safety endpoints in Puerto Ricans.

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CYP2D6’s functional status associated with the length of hospitalization stay in psychiatric patients: a twist in the tale or evidence that matters?

Duconge J, Cadilla CL. CYP2D6’s functional status associated with the length of hospitalization stay in psychiatric patients: a twist in the tale or evidence that matters? Biomark Med. 2013 Dec;7(6):913-4. doi: 10.2217/bmm.13.109.

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Ocular Findings in Patients with the Hermansky-Pudlak Syndrome (Types 1 and 3)

Jardón J, Izquierdo NJ, Renta JY, García-Rodríguez O, Cadilla CL. Ocular Findings in Patients with the Hermansky-Pudlak Syndrome (Types 1 and 3).

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Paramagnetic dithiolene complexes as metallo-ligands: ether/thioether coordination

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Spin crossover or intramolecular electron transfer in a cyanido-bridged Fe/Co dinuclear dumbbell: a matter of state

Jeon; S. Calancea;A. Panja; D. Piñero; P. Dechambenoit; C. Coulon; A. Wattiaux; P. Rosa; C. Mathonière; R. Clérac, “Spin crossover or intra-molecular electron transfer in a cyanido-bridged Fe/Co dinuclear dumbbell: a matter of state”, Chem. Sci., 20134, 2463-2470.

Bioelectrochemistry of non-covalent immobilized alcohol dehydrogenase on oxidized diamond nanoparticles

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Catalytic effect of ultrananocrystalline Fe3O4 on algal bio-crude production via HTL process.

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The α7 nicotinic receptor is up-regulated in macrophages from HIV-seropositive women: Consequences to the cholinergic anti-inflammatory response Clinical & Translational Immunology

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Expression of CHRFAM7A and CHRNA7 in neuronal cells and postmortem brain of HIV-infected patients: considerations for HIV-associated neurocognitive disorder.

Ramos FM, Delgado-Vélez M, Ortiz ÁL, Báez-Pagán CA, Quesada O, Lasalde-Dominicci JA. Expression of CHRFAM7A and CHRNA7 in neuronal cells and postmortem brain of HIV-infected patients: considerations for HIV-associated neurocognitive disorder. J Neurovirol. 2015 Nov 13. [Epub ahead of print]

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Assessment of the functionality and stability of detergent purified nAChR from Torpedo using lipidic matrixes and macroscopic electrophysiology.

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Lateral Diffusion, Function, and Expression of the Slow Channel Congenital Myasthenia Syndrome αC418W Nicotinic Receptor Mutation with Changes in Lipid Raft Components.

Oyola-Cintrón J, Caballero-Rivera D, Ballester L, Baéz-Pagán CA, Martínez HL, Vélez-Arroyo KP, Quesada O, Lasalde-Dominicci JA. Lateral Diffusion, Function, and Expression of the Slow Channel Congenital Myasthenia Syndrome αC418W Nicotinic Receptor Mutation with Changes in Lipid Raft Components. J Biol Chem.2015 Oct 30;290(44):26790-800. doi: 10.1074/jbc.M115.678573. Epub 2015 Sep 9. PubMed PMID: 26354438;

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Engineering α4β2 nAChRs with reduced or increased nicotine sensitivity via selective disruption of consensus sites in the M3-M4 cytoplasmic loop of the α4 subunit.

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Activation of the Macrophage α7 Nicotinic Acetylcholine Receptor and Control of Inflammation.

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Fluoxetine is neuroprotective in slow-channel congenital myasthenic syndrome.

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Transgenic mouse model reveals an unsuspected role of the acetylcholine receptor in statin-induced neuromuscular adverse drug reactions.

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SorLA in glia: shared subcellular distribution patterns with caveolin-1.

Salgado IK, Serrano M, García JO, Martínez NA, Maldonado HM, Báez-Pagán CA, Lasalde-Dominicci JA, Silva WI. SorLA in glia: shared subcellular distribution patterns with caveolin-1. Cell Mol Neurobiol. 2012 Apr;32(3):409-21. doi: 10.1007/s10571-011-9771-5. Epub 2011 Nov 30.

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Up-regulation of the neuronal nicotinic receptor α7 by HIV glycoprotein 120: potential implications for HIV-associated neurocognitive disorder.

Ballester LY, Capó-Vélez CM, García-Beltrán WF, Ramos FM, Vázquez-Rosa E, Ríos R, Mercado JR, Meléndez RI, Lasalde-Dominicci JA. Up-regulation of the neuronal nicotinic receptor α7 by HIV glycoprotein 120: potential implications for HIV-associated neurocognitive disorder. J Biol Chem. 2012 Jan 27;287(5):3079-86. doi: 10.1074/jbc.M111.262543. Epub 2011 Nov 14.

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Tuning thermoresponsive supramolecular G-quadruplexes.

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A photoresponsive supramolecular G-quadruplex.

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Patchy supramolecules as versatile tools to probe hydrophobicity in nanoglobular systems.

Negrón LM, Meléndez-Contés Y, Rivera JM. Patchy supramolecules as versatile tools to probe hydrophobicity in nanoglobular systems. J Am Chem Soc. 2013 Mar 13;135(10):3815-7. doi: 10.1021/ja401373h. Epub 2013 Feb 27.

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An aquatic host-guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin.

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Graphene oxide as a protein matrix: influence on protein biophysical properties.

Hernández-Cancel G, Suazo-Dávila D, Ojeda-Cruzado AJ, García-Torres D, Cabrera CR, Griebenow K. Graphene oxide as a protein matrix: influence on protein biophysical properties. J Nanobiotechnology. 2015 Oct 19;13(1):70. doi:10.1186/s12951-015-0134-0.

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Purification and characterization of a cytochrome c with novel caspase-3 activation activity from the pathogenic fungus Rhizopus arrhizus.

Saxena M, Sharma RK, Ramirez-Paz J, Tinoco AD, Griebenow K. Purification and characterization of a cytochrome c with novel caspase-3 activation activity from the pathogenic fungus Rhizopus arrhizus. BMC Biochem. 2015 Sep 3;16:21. doi: 10.1186/s12858-015-0050-9.

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The cytotoxicity of BAMLET complexes is due to oleic acid and independent of the α-lactalbumin component.

Delgado Y, Morales-Cruz M, Figueroa CM, Hernández-Román J, Hernández G, Griebenow K. The cytotoxicity of BAMLET complexes is due to oleic acid and independent of the α-lactalbumin component. FEBS Open Bio. 2015 May 4;5:397-404. doi: 10.1016/j.fob.2015.04.010. eCollection 2015.

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Chemically glycosylation improves the stability of an amperometric horseradish peroxidase biosensor.

Hernández-Cancel G, Suazo-Dávila D, Medina-Guzmán J, Rosado-González M, Díaz-Vázquez LM, Griebenow K. Chemically glycosylation improves the stability of an amperometric horseradish peroxidase biosensor. Anal Chim Acta. 2015 Jan 7;854:129-39. doi: 10.1016/j.aca.2014.11.008. Epub 2014 Nov 7.

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A comparative study of different protein immobilization methods for the construction of an efficient nano-structured lactate oxidase-SWCNT-biosensor.

Pagán M, Suazo D, Del Toro N, Griebenow K. A comparative study of different protein immobilization methods for the construction of an efficient nano-structured lactate oxidase-SWCNT-biosensor. Biosens Bioelectron. 2015 Feb 15;64:138-46. doi: 10.1016/j.bios.2014.08.072. Epub 2014 Sep 3.

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Activation of caspase-dependent apoptosis by intracellular delivery of Cytochrome c-based nanoparticles.

Morales-Cruz M, Figueroa CM, González-Robles T, Delgado Y, Molina A, Méndez J, Morales M, Griebenow K. Activation of caspase-dependent apoptosis by intracellular delivery of Cytochrome c-based nanoparticles. J Nanobiotechnology. 2014 Sep 2;12:33. doi: 10.1186/s12951-014-0033-9.

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Chemical glycosylation of cytochrome c improves physical and chemical protein stability.

Delgado Y, Morales-Cruz M, Hernández-Román J, Martínez Y, Griebenow K. Chemical glycosylation of cytochrome c improves physical and chemical protein stability. BMC Biochem. 2014 Aug 6;15:16. doi: 10.1186/1471-2091-15-16.

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Delivery of chemically glycosylated cytochrome c immobilized in mesoporous silica nanoparticles induces apoptosis in HeLa cancer cells.

Méndez J, Morales Cruz M, Delgado Y, Figueroa CM, Orellano EA, Morales M, Monteagudo A, Griebenow K. Delivery of chemically glycosylated cytochrome c immobilized in mesoporous silica nanoparticles induces apoptosis in HeLa cancer cells. Mol Pharm. 2014 Jan 6;11(1):102-11. doi: 10.1021/mp400400j. Epub 2013 Dec 10.

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Glycosylation improves α-chymotrypsin stability upon encapsulation in poly(lactic-co-glycolic)acid microspheres.

Flores-Fernández GM, Griebenow K. Glycosylation improves α-chymotrypsin stability upon encapsulation in poly(lactic-co-glycolic)acid microspheres. Results Pharma Sci. 2012;2:46-51.

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Two-step nanoprecipitation for the production of protein-loaded PLGA nanospheres.

Morales-Cruz M, Flores-Fernández GM, Morales-Cruz M, Orellano EA, Rodriguez-Martinez JA, Ruiz M, Griebenow K. Two-step nanoprecipitation for the production of protein-loaded PLGA nanospheres. Results Pharma Sci. 2012;2:79-85.

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Improved enzyme activity and stability in polymer microspheres by encapsulation of protein nanospheres.

Montalvo-Ortiz BL, Sosa B, Griebenow K. Improved enzyme activity and stability in polymer microspheres by encapsulation of protein nanospheres. AAPS PharmSciTech. 2012 Jun;13(2):632-6. doi: 10.1208/s12249-012-9794-3. Epub 2012 Apr 27.

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Stimulus-responsive controlled release system by covalent immobilization of an enzyme into mesoporous silica nanoparticles.

Méndez J, Monteagudo A, Griebenow K. Stimulus-responsive controlled release system by covalent immobilization of an enzyme into mesoporous silica nanoparticles. Bioconjug Chem. 2012 Apr 18;23(4):698-704. doi: 10.1021/bc200301a. Epub 2012 Mar 13.

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Bioelectrochemistry of non-covalent immobilized alcohol dehydrogenase on oxidized diamond nanoparticles.

Nicolau E, Méndez J, Fonseca JJ, Griebenow K, Cabrera CR. Bioelectrochemistry of non-covalent immobilized alcohol dehydrogenase on oxidized diamond nanoparticles. Bioelectrochemistry. 2012 Jun;85:1-6. doi: 10.1016/j.bioelechem.2011.11.002. Epub 2011 Nov 20.

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Revealing Polymorphic Phase Transformations in Polymerbased Hot-Melt Extrusion Processes

Hernández Espinell, J. R.; López-Mejías, V.; Stelzer T.

Structure-Polymorphism Study of Fenamates: Toward Developing an Understanding of the Polymorphophore

López-Mejías, V.; Matzger, A.J.

Towards Control of Nucleation and Encapsulation with Alginate Hydrogels: A Biocompatible Vehicle for Hydrophilic and Hydrophobic Drugs

López-Mejías, V.; Eral, H.B.; Doyle, P.S.; Myerson, A.S.

Regulating Nucleation Kinetics Through Molecular Interactions at the Polymer-Solute Interface

Curcio, E.; López-Mejías, V.; Di Profio, G.; Fontananovam E.; Drioli, E.; Trout, B.L.; Myerson, A.S.

Geometric Design of Heterogeneous Nucleation Sites on Biocompatible Surfaces

López-Mejías, V.; Myerson, A.S.; Trout, B.L.

Nonamorphism in Flufenamic acid and a New Record for a Polymorphic Compound with Solved Structures

López-Mejías, V.; Kampf, J.W.; Matzger, A.J.

On the Mechanism of Polymorph Selection by Polymer Heteronuclei, Langmuir

López-Mejías, V.; Knight, J.L.; Matzger, A.J.; Brooks III C.L.

Peering at a Buried Polymer-Crystal Interface: Probing Heterogeneous Nucleation by Sum Frequency Generation Vibrational Spectroscopy,

McClelland, A.A.; López-Mejías, V.; Matzger, A.J.; Chen, Z.

Polymer-Induced Heteronucleation of Tolfenamic Acid: Structural Investigation of a Pentamorph

López-Mejías, V.; Kampf, J.W.; Matzger, A.J.

Chemtob S. Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis

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Revealing Polymorphic Phase Transformations in Polymer-Based Hot Melt Extrusion Processes

Hernández Espinell, J.R., López-Mejías, V., Stelzer, T.

Advanced Continuous Flow Platform for On-Demand Pharmaceutical Manufacturing

Zhang, P., Weeranoppanant, N., Thomas, D.A., Tahara, K., Stelzer, T., Russell, M.G., O’Mahony, M., Myerson, A.S., Lin, H., Kelly, L.P., Jensen, K.F., Jamison, T.F., Dai, C., Cui, Y., Briggs, N., Beingessner, R.L., Adamo, A.

Evaluation of PAT Methods for Potential Application in Small-Scale, Multi-purpose Pharmaceutical Manufacturing Platforms

Stelzer, T., Wong, S.Y., Chen, J., Myerson, A.

Compact and Integrated Approach for Advanced End-to-end Production, Purification, and Aqueous Formulation of Lidocaine Hydrochloride

Monbaliu, J.-C., Stelzer, T., Revalor, E., Weeranoppanant, N.; Jensen, K.F.; Myerson, A.S.

Custom-Built Miniature Continuous Crystallization System with Pressure-Driven Suspension Transfer

Cui, Y., O’Mahony, M., Jaramillo, J.J., Stelzer, T., Myerson, A.S.

On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system.

Adamo, A., Beingessner, R.L., Chen, J., Jamison, T.F., Jensen, K.F., Monbaliu, J.-C., Myerson, A.S. Revalor, E., Snead, D.R., Stelzer, T., Weeranoppanant, N., Wong, S.Y., Zhang, P

Monitoring Concept of Single-frequency Ultrasound and its Application in Dynamic Crystallization Processes

Cui, Y., Jaramillo, J.J., Stelzer, T., Myerson, A.S.

Ultrasonic Crystallization Monitoring Technique for Simultaneous in-line Measurement of Liquid and Solid Phase

Stelzer, T., Pertig, D., Ulrich, J.

Crystalline Coats or Hollow Crystals as Tools for Product Design in Pharmaceutical Industry, J. Cryst. Growth

Ulrich, J., Schuster, A., Stelzer, T.

Rate of sodium chloride attrition fragment generation in a mixed-suspension crystallizerRate of sodium chloride attrition fragment generation in a mixed-suspension crystallizer

Mueansichai, T., Flood, A. E., Stelzer, T., Ulrich, J.

Insights into the Evaporation Kinetics of Indomethacin Solutions

Hellstén, S., Han, B., Mäkilä, E., Niemi, H., Salonen, J., Lehto, V.-P., Stelzer, T., Louhi-Kultanen, M., Ulrich, J.

Structural Investigation on Sodium-2-Keto-L-Gulonate-Monohydrate

Dette, S.S., Sanselme, M., Stelzer, T., Renou, L., Jones, M.J., Couvrat, N., Coquerel, G., Ulrich, J.

Bubbles – Trouble-Makers in Crystallizers Classical Problems during Inline Measurements

Helmdach, L., Pertig, D., Rüdiger, S., Lee, K.-S., Stelzer, T., Ulrich, J.

Formation of Crystalline Hollow Whiskers as Relics of Organic Dissipative Structures, Cryst. Growth

Martins, D., Stelzer, T., Ulrich, J., Coquerel, G.

In-line Analyzing of Industrial Crystallization Processes by an Innovative Ultrasonic Probe Technique

Pertig, D., Buchfink, R., Petersen, S., Stelzer, T., Ulrich, J.

Decreasing the Diameter of Crystalline Tubes and an Approach to Explain its Nucleation, Chem. Eng. Technol.

Wachsmuth, A., Stelzer, T., Ulrich, J.

The Generation of Crystalline Hollow Needles: New Approach by Liquidliquid Phase Transformation

Schuster, A., Stelzer, T., Ulrich, J

Industrial Crystallization: Still a vivid topic!

Stelzer, T., Ulrich , J.

Investigation of Water Adsorption of Crystalline Fertilizer

Rößler, M., Stelzer, T., Ulrich, J.

Werkzeuge für’s Produktdesign - Industrielle Kristallisation vom Molekül bis zur Anlage

Rüdiger, S., Stelzer, T., Ulrich, J.

Crystallization a Tool for Product Design

Stelzer, T., Ulrich, J.

No Product Design without Process Design (Control)?

Stelzer, T., Ulrich, J.

Closed Crystalline Tubes as a Container System

Schuster, A., Stelzer, T., Petersen, S., Ulrich, J.

Fascinating control of crystalline microstructures

Dette, S.S., Stelzer, T., Jones, M. J., Coquerel, G., Ulrich, J.

Dehydration behavior of hydrates

Dette, S.S., Stelzer, T., Jones, M. J., Ulrich, J.

Was gibt es neues im Bereich der Kristallisation?

Stelzer, T

Is control of the storage stability of fertilizer granules by additives feasible?

Stelzer, T., Ulrich, J.

Controlling the internal diameter of nanotubes by changing the concentrations of the antisolvent

Dette, S.S., Stelzer, T., Römbach, E., Jones, M. J., Ulrich, J.

Acid-functionalized mesoporous carbon: an efficient support for ruthenium-catalyzed γ-valerolactone production.

Villa A, Schiavoni M, Chan-Thaw CE, Fulvio PF, Mayes RT, Dai S, More KL, Veith GM, Prati L. Acid-functionalized mesoporous carbon: an efficient support for ruthenium-catalyzed γ-valerolactone production. ChemSusChem. 2015 Aug 10;8(15):2520-8. doi: 10.1002/cssc.201500331. Epub 2015 Jun 18.

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Aqueous proton transfer across single-layer graphene.

Achtyl JL, Unocic RR, Xu L, Cai Y, Raju M, Zhang W, Sacci RL, Vlassiouk IV, Fulvio PF, Ganesh P, Wesolowski DJ, Dai S, van Duin AC, Neurock M, Geiger FM. Aqueous proton transfer across single-layer graphene. Nat Commun. 2015 Mar 17;6:6539. doi: 10.1038/ncomms7539.

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Expression profile of flotillin-2 and its pathophysiological role after spinal cord injury.

Santiago JM, Torrado AI, Arocho LC, Rosas OR, Rodríguez AE, Toro FK, Salgado IK, Torres YA, Silva WI, Miranda JD. Expression profile of flotillin-2 and its pathophysiological role after spinal cord injury. J Mol Neurosci. 2013 Feb;49(2):347-59. doi: 10.1007/s12031-012-9873-7. Epub 2012 Aug 10.

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SorLA in glia: shared subcellular distribution patterns with caveolin-1.

Salgado IK, Serrano M, García JO, Martínez NA, Maldonado HM, Báez-Pagán CA, Lasalde-Dominicci JA, Silva WI. SorLA in glia: shared subcellular distribution patterns with caveolin-1. Cell Mol Neurobiol. 2012 Apr;32(3):409-21. doi: 10.1007/s10571-011-9771-5. Epub 2011 Nov 30.

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